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Funding This work and associated article processing charges were supported by Eli Lilly and Company
In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]
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Significantly, GLP-1RAs demonstrate favorable protective effects against hepatocellular and prostate cancer
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