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GLP-1RA Therapy as a Chronic Flux Perturbation System-Level Energy Flux Reorganization Under Weight Loss Therapy Most weight-loss interventionsincluding exercise [49], calorie restriction [50], cold exposure [51], and selected antidiabetic agents [10, 52]ultimately increase reliance on FAO, which supplies acetyl-CoA to sustain tricarboxylic acid (TCA) cycle activity and electron transport chain (ETC)coupled adenosine triphosphate (ATP) production

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doi: 10.1016/0006-8993(92)90432-9

Efficacy and safety of glucagon-like peptide-1/glucagon receptor co-agonist JNJ-64565111 in individuals with type 2 diabetes mellitus and obesity: a randomized dose-ranging study

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