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Fiona Gribble (University of Cambridge, UK)

Based on the encouraging efficacy of GLP-1/glucagon and GLP-1/GIP co-agonists, it was rationalized that a single molecule with triple agonism at all three of these receptors might provide even greater efficacy than the respective co-agonists

However, anaesthetists must take into account the theoretical increased risk of aspiration in patients taking GLP-1 agonists, as presented by the aforementioned case reports

So, not only do you run the risk of your face looking more gaunt and sunken after using a GLP-1 medication, youre also facing your hair potentially peacing out

The high demand and high cost of these medications create incentives for inappropriate prescribing, prescription diversion, or attempts to obtain medication without proper clinical evaluation

The trials above indicate that once-weekly exenatide should be given to patients with other medications for a few weeks to ensure that optimum glycemic control is achieved, since the steady state concentrations of once-weekly exenatide are reached within 1 week6)