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These drugs are both dopamine and cholinergic receptor antagonists that act on the area postrema in the brainstem

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doi: 10.2337/dc12-2454

234 The nonsteroidal anti-inflammatory drug diclofenac can significantly reduce the protein expression level of NF-B p65 and the phosphorylation level of IB-, effectively protecting the structure and function of the intestinal barrier by suppressing the iNOS/NF-B pathway and activating the expression of HO-1