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Cost-effectiveness analysis of five anti-obesity medications from a US payers perspective

Unlike brand-name GLP-1s, these products are not FDA-approved, so safety, purity, and effectiveness may vary

Landmark preclinical studies using animal knockouts have demonstrated that GLP-1 receptors in the brain are capable of controlling food intake and body weight, in addition to the hypophagic effects of endogenous GLP1 via peripheral GLP1 receptors [33]

Understanding these potential side effects allows for better preparation and management

Both tirzepatide and retatrutide have undergone rigorous clinical trials, and the weight loss data from these studies provides the most reliable comparison available

In a meta-analysis that included over 2000 patients treated with canagliflozin 100 mg or 300 mg vs