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In this episode of HeartBrief, Joel Kahn, MD, reviews three impactful developments in cardiometabolic health

That volume knob gets turned up

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Lincoff is also optimistic, but he notes that cardiologists will need to gain familiarity with using the GLP-1 RAs and tirzepatide

Is your mouth clean and appropriately moist when you dose

Retatrutide (LY3437943): Investigational Triple Agonist for Obesity & Metabolic Disease Current Status (February 2026): Investigational only