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The Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) is reviewing data on the risk of suicidal thoughts and thoughts of self-harm with glucagon-like peptide-1 agonist (GLP-1a), including Ozempic (semaglutide), Saxenda (liraglutide) and Wegovy (semaglutide)

Serena Williams opens up about GLP-1 use as a celebrity ambassador for Ro.

#Semaglutide improves heart failure-related symptoms and physical function and results in greater weight loss compared with placebo in patients with #HFpEF and #obesity #ESCCongress STEP-HFpEF trial

Methods C57BL/6J mice and Sirt1 +/ mice were treated with exenatide (24 nmol/kg) or an NaCl solution (154 mmol/l) control i.p

Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

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