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Saxenda, are approved for use in New Zealand as adjunctive treatments for weight loss (not funded)
As a result, simply injecting GLP-1 itself was impractical it would be cleared before having sustained benefit

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With its ability to significantly impact weight loss and improve metabolic health, Tirzepatide injections offer a promising avenue for individuals striving to overcome the challenges of obesity and achieve a healthier, more active lifestyle

Fasting insulin and the homeostatic model assessment (HOMA-IR, derived from fasting glucose and insulin) are the most common and practical surrogates, and they are the measures that move so dramatically in the retatrutide trials

The GLP-1 analogs liraglutide and semaglutide reduce atherosclerosis in ApoE/ and LDLr/ mice by a mechanism that includes inflammatory pathways
