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During perimenopause, the gradual decline in oestrogen, progesterone and testosterone can bring brain fog, insomnia, anxiety, low mood, weight redistribution, and changes in libido

Blood pressure control was unaffected in the LEADER trial (N=9,340), where 82% of patients were on renin-angiotensin system inhibitors and no signal of hypertension worsening appeared [19]

The relative risks of complications, including progression of CKD to end-stage kidney disease (ESKD), CVD and mortality, are increased with both reduced eGFR and elevated UACR levels [1]

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Previous research Observational studies and meta-analyses of RCTs on fracture risk with GLP-1 RAs have found mostly neutral effects ( However, studies on markers of bone health point towards direct beneficial effects of GLP-1 RAs on bone

In plain terms, it may help patients who feel like their eating is less about physical hunger and more about urges, stress, or emotional triggers