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Harms and Benefits of Sodium-Glucose Co-Transporter 2 Inhibitors

Exendin-4 protects against postmyocardial infarction remodeling via specific actions on inflammation and the extracellular matrix

Bergmann NC, Lund A, Gasbjerg LS, Meessen ECE, Andersen MM, Bergmann S, et al

Doctors may prescribe GLP-1 agonists to people with type 2 diabetes who have poor blood sugar control and are taking anti-diabetic therapy by mouth

13,14 This reduction in MACE, which is not explained by improvements in glycaemia and nonglycaemic cardiovascular risk factors, remains to be fully elucidated but may reflect other effects of GLP-1 analogues such as their antioxidative and anti-inflammatory properties

Keywords: GLP-1 receptor agonist, GIP receptor agonist, Semaglutide, Tirzepatide, Diabetes mellitus type 2, Obesity Glucagon-like peptide-1 (GLP-1) and combination GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist medications (Table) mimic natural incretin hormones produced by the gut that have a critical role in digestion and glucose homeostasis