glp 1 analogue drugs Trends in the Development of GLP-1 Receptor Agonists GLP-1 Receptor Agonists as Treatments

[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Brown J.C., Pederson R.A., Jorpes E., Mutt V

(A) GLP-1 can induce fibronectin type III domain-containing protein 5 (FNDC5) expression in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT)

In 2021, AMG133, a bispecific molecule that combines GIP receptor antagonism and GLP-1 receptor agonism was presented

Neurosci Biobehav Rev 26 , 393428 (2002)

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