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Description
Retatrutide is a triple agonist (GIP/GLP-1/glucagon receptor) studied in advanced metabolic research applications
In this paper, the authors describe the energy state-dependent regulation of the PVNGLP-1R to DVC circuit, resulting in altered food intake and metabolic health, mediated by GLP-1 receptor signalling.
Data on other compounds such as DDP-4 and SGLT-2 inhibitors are limited
ClinicalTrials.gov identifiers NCT01037582, NCT01686945.
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