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doi: 10.1016/j.cmet.2012.04.022

The notion that reduced GLP-1 concentrations would result in a reduction of the prokinetic actions of GLP-1 in the colon (27), causing constipation and abdominal pain, was further supported by the correlation between this and the intensity of abdominal discomfort (28)

Jin ES, Malloy CR, Sharma G, Finn E, Fuller KN, Reyes YG, et al

As the body sheds pounds and reshapes, its completely normal for the skin and underlying tissues to change as well, sometimes resulting in loose or lax skin