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In this regard, the pleiotropic actions of two or three different receptor agonists may be additive but also complimentary to each other, thus being possibly more effective than GLP-1RAs in multifactorial diseases, including obesity, T2DM, and NAFLD [42]

Weight gain and weight-loss resistance may involve insulin response, energy expenditure, fat storage, inflammation, sleep patterns, stress hormones, genetics, and lifestyle habits

This can have effects on the acceptance of therapy or adherence in a patient with type 2 diabetes [20]

PMID: 39453660

By the second half of 2015, there were approximately 1.1 million prescriptions filled for Invokana, 411,000 for Farxiga (dapagliflozin) and 136,000 for Jardiance (empagliflozin)

It is a hormone the body already produces, provided the right signals are present
