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But whether GLP-1s will deliver meaningful weight loss for athletes already in tip-top shape is an open question

Participants were randomized to receive weekly injections of tirzepatide at 5 mg, 10 mg, or 15 mg, or placebo, for 72 weeks

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The liver contains GLP-1 receptors, and activation appears to directly reduce hepatic lipogenesis (fat production in the liver), increase fatty acid oxidation, and reduce inflammatory signaling in hepatocytes

Tirzepatide targets GLP-1 and GIP receptors , while retatrutide adds glucagon receptor activation to that mechanism