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While Mounjaro is designed to manage type 2 diabetes, Zepbound is approved for chronic weight management

Nausea occurred in about 28% of participants at the 12 mg dose, which is notably lower than Semaglutides 44% nausea rate
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When GLP-1 receptor agonists chronically stimulate these receptors, the C-cells proliferate

This is also why constipation is so common on these drugs, affecting an estimated 5 to 24% of users : less fiber and less fluid meet a slowed gut all at once

In addition, insulin resistance contributes to systemic inflammation and oxidative stress, both of which can impair spermatogenesis
