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Description
Five of the nineteen studies used exenatide [9,17,21,34,36] as the GLP-1 receptor agonist, one study used semaglutide [18], and thirteen studies used liraglutide [22,23,24,25,26,27,28,29,30,31,32,33,35]
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Characteristics of therapeutic GLP-1R agonists Endogenous GLP-1 is characterized by a very short half-life of only few minutes, as it is quickly degraded by dipeptidyl peptidase-4 (DPP4), an enzyme expressed in many different types of tissues
Nearer-Term Availability Survodutide Phase 3 SYNCHRONIZE trials fully enrolled with results expected H1 2026, potentially positioning survodutide for regulatory submission before retatrutide Phase 3 data matures
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