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Its biology fighting a toxic environment

Clinical data analysis suggests that metformin use reduces the risk of malignancies by approximately 30% [10] and significantly decreases tumor-related mortality in patients with type 2 diabetes [103]
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Obesity in late adolescence and incident type 1 diabetes in young adulthood
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GLP-1 and intestinal diseases

This is a composite, and individual results vary widely but it captures a pattern I now see often enough that I ask about metabolic inflammation at nearly every RA visit