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It is metabolically active tissue that secretes inflammatory cytokines, disrupts insulin signaling, and contributes to cardiovascular disease risk

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Clinical trials demonstrate that tirzepatide alone produces substantial weight loss when: Doses are appropriately titrated (starting at 2.5 mg weekly, increasing by 2.5 mg every 4 weeks as tolerated up to 15 mg) Treatment is combined with comprehensive lifestyle modification Patients receive ongoing dietary counselling and behavioural support Adequate time is allowed (typically 612 months) to assess full therapeutic effect Many patients who feel treatment is insufficient may benefit from dose optimisation or addressing adherence barriers rather than adding another medication

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