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And while everyone taking a weight-loss medication should prioritize diet and exercise, it becomes even more important when youre microdosing

9 Research gaps and future priorities 9.1 Reproductive-oriented RCTs: shifting from metabolic surrogates to hard endpoints To date, most GLP-1RA trials in PCOS have been designed around metabolic efficacy (weight change and insulin-resistance/glycaemic indices) as the primary outcomes, with reproductive outcomesovulation, clinical pregnancy, and live birthreported inconsistently and often as secondary or exploratory measures

J Am Coll Cardiol (2022) 80(25):236171

however, incidence of this adverse event in clinical trials was very low [21]

Diabetes 46 , 785791 (1997)

Taking a medication roughly 12 times a year could materially increase adherence rates