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In addition to their insulinotropic effects, GIP and GLP-1 play critical roles in various biological processes in different tissues and organs that express their receptors, including the pancreas, adipose tissue, bone, and the brain
In the ATTAIN-MAINTAIN trial, orforglipron's profile was "consistent with previous orforglipron Phase 3 studies." The most common adverse events were gastrointestinal-related and were generally mild-to-moderate in severity, which is expected for the GLP-1 class

Researchers interested in replicating or extending this work may request access to the TriNetX platform (Available online: through their affiliated institutions, subject to approval by TriNetX and compliance with their data use policies

[PubMed ID: 24531224]

This means semaglutide offers more benefits than just weight loss
