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Zepbound vs Wegovy Weight Loss Results Zepbound has demonstrated greater average weight loss in clinical trials compared to Wegovy: Zepbound led to as much as a 20.9% average reduction in body weight at the highest 15 mg dose over 72 weeks, according to results from the SURMOUNT-1 trial

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Significant results highlight the effectiveness of higher doses (e.g., 70.3 lbs loss) for substantial long-term weight control

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Dose Escalation Protocol and Timeline The standard semaglutide titration schedule introduces small weekly dose increments spaced four weeks apart to allow your body time to establish new set points for hunger and satiety signals