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To establish the T2DM model, after 8 weeks of HFD (10% lard, 20% sucrose, 2.5% cholesterol, 1% bile salt, and 66.5% regular diet), rats received the intraperitoneal (i.p.) injection of 35 mg/kg STZ (Sigma) after overnight fasting

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These findings suggest that GLP-1 receptor agonists may be an option worth considering for type 2 diabetes patients at risk of RVO, potentially contributing to favorable long-term ocular outcomes and reducing the burden of visual impairment in this population, the researchers concluded in their paper.

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