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Combination approach needed

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It May Lower Cardiovascular Risk Some studies suggest that yerba mate can boost HDL (aka good) cholesterol and lower LDL (aka bad) cholesterol, total cholesterol, and triglyceridesin turn, potentially lowering cardiovascular risk in both healthy and moderately at-risk populations

In particular, the SAVOR-TIMI 53 (Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus) clinical trial evidenced neutral effects of saxagliptin in terms of cardiovascular outcomes, but an increased risk of hospitalization for HF, especially in patients with high levels of natriuretic peptides, previous HF, or chronic kidney disease [148]