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doi: 10.3390/ijms25073812 85

Although the roles of resistin, a hormone produced and secreted from mature adipocytes and macrophages 37,38 , may vary between physiological and pathophysiological states and among species 39 , several reports suggest that in mice, resistin directly affects glucose metabolism by antagonizing insulin action 40,41

The two major incretins are GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

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Diabetes Res Clin Pract 174:108737 Ke Z, Ma Q, Ye X, Wang Y, Jin Y, Zhao X et al (2024) Peptide GLP-1 receptor agonists: from injection to oral delivery strategies

It rose gradually during the dose-escalation phase, peaked around week 24, and then declined at weeks 36 and 48 even though participants continued taking the same dose