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In subjects with severe RI, the mean exposure of semaglutide was 22% higher than in subjects with normal renal function, and the 95% confidence interval (1.021.47) for the ratio exceeded the pre-specified limits (0.701.43)

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The Glucagon-like peptide (GLP-1) receptor agonist semaglutide could help PLWH lose weight gained after starting ARTbut it may also exacerbate muscle loss or lipoatrophy.

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