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Orexigenic and anorexigenic neurones possess GLP-1 R so that GLP-1 binding promotes satiety [25]
Our results reveal the existence of residue networks crucial for unimolecular agonist-mediated receptor activation and their distinct signaling patterns, which might be useful to the rational design of biased drug leads

doi: 10.1007/s40259-013-0057-y 127 McCartyDColemanMBolandCL

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