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If you've reached 7.5+ mg with no changes after 12 weeks, genetic factors may indicate you'd respond better to semaglutide or a dual compound like GLP-Squaredask your PlexusDx provider about the Precision Peptide Genetic Test to optimize your protocol

A separate meta-analysis quantified the threshold data: the relative risk of achieving 5% weight loss was 2.92

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The SURMOUNT-4 withdrawal trial showed that patients regain approximately half of lost weight within one year of stopping tirzepatide, highlighting that obesity is a chronic disease requiring ongoing management rather than a condition cured by temporary treatment

Some of the most common side effects of semaglutide are: Vomiting, upset stomach, stomach pains, Constipation, Diarrhea, Heartburn, Acid reflux, Belching and gas, Dizziness, Headaches and fatigue

"So if GLP-1s have the potential to decrease cancer risks outside obesity alone, those patients may stand to benefit," she says