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Resting energy expenditure (REE) and respiratory quotient (RQ) were measured by indirect calorimetry

189,190 In addition, the mitochondrial PGC-1 signaling pathway is also the mechanism of GLP-1 RA to protect neurons from tau hyperphosphorylation, indicating that mitochondrial dysregulation has crosstalk with tau pathology

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the extent of this brain penetration, however, is under debate and has been suggested to cover only the hypothalamus and hindbrain (140) or extend to many other populations including those found deep in the brain, for example in the hippocampus or NAc (27, 141, 142)