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Most notably, the highest dose of retatrutide (12 mg) led to 24.2% weight loss (vs 2.1% with placebo) at 48 weeks
However, their efficacy is driven primarily by appetite suppression rather than sustained increases in energy expenditure, and adult human physiology imposes a clear ceiling on thermogenic contributions
[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Kang YM, et al
Among these effects are significant changes in gastric motility
Most people see significant results within three to six months
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