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82 In type 2 diabetes-associated cognitive impairment animal models and high-glucose in vitro studies, neuroinflammatory markers, such as IL-1 , TNF-, IL-6, and MCP-1, and inflammatory responses, such as toll-like receptor 4, cyclooxygenase 1 (COX1), COX2, NF-B, leukocyte common antigen, and inducible nitric oxide synthase were increased in the brain

In contrast, the FREEDOM trial reported that the constant infusion of exenatide (20 ug daily for 3 months followed by 60 g daily) through an osmotic minipump was non-inferior to the placebo in 4156 T2DM patients (with a median follow-up of 16 months) (Ruff et al

Healthy fats and oils Monounsaturated fats (such as those found in olive oil and avocados) have been shown to cause an increase in GLP-1 levels, particularly compared to saturated fats (such as butter and red meats) [3]

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