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The GIP component enhances insulin secretion and contributes to adipose tissue metabolism

Several hormonal factors make belly fat particularly stubborn

These effects were accompanied by decreased GLP-1R plasma membrane diffusion under vehicle conditions, measured by Raster Image Correlation Spectroscopy (RICS) in rat insulinoma INS-1 832/3 cells with endogenous GLP-1R deleted [INS-1 832/3 GLP-1R KO cells (27)] stably expressing SNAP/FLAG-tagged human GLP-1R (SNAP/FLAG-hGLP-1R), an effect that is normally triggered by agonist binding (28), as also observed here (Supplementary Figure 1C, D)

Proteinprotein docking dealing with the unknown

Ebenso interessant ist die Vorstellung von Survodutid, einer neuartigen Verbindung, die als dualer Agonist fr sowohl Glukagon-Rezeptoren als auch Glukagon-hnliche Peptid-1-Rezeptoren wirkt

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