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Ozempic is approved for diabetes (Wegovy is the weight-loss-approved semaglutide) Both have cardiovascular outcome data, though semaglutides is stronger Cost is comparable at cash-pay prices, though insurance coverage varies Semaglutide has largely replaced liraglutide as the preferred GLP-1 for weight loss Switching from Saxenda to semaglutide is straightforward and commonly done For most patients, semaglutide is the better choice due to greater effectiveness and dosing convenience Understanding the GLP-1 Class Before comparing these specific medications, understanding the GLP-1 class explains why they share similarities while differing in potency

GLP-1 prescriptions for those aged 18 to 39 increased 588%, from 0.19% in 2019 to 1.33% in 2024

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GLP-1 therapy works best for patients motivated to adopt lifestyle changes alongside medication use