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Receptor desensitization : Over time, GLP1 receptors may become less responsive to consistent drug exposure, reducing the appetite-suppressing effect
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[42].Henry RR, Logan D, Alessi T, Baron MA, A Randomized, Open-Label, Multicenter, 4-Week Study to Evaluate the Tolerability and Pharmacokinetics of ITCA 650 in Patients With Type 2 Diabetes, Clinical therapeutics, 35 (2013) 634645
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