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Non-gangrenous IC usually requires only conservative therapy, including repeated careful assessment, pain control, and fluid replacement, and is associated with a good prognosis.16 Surgical management may be necessary if there are signs of deterioration, perforation, hemorrhage, or sepsis

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Retatrutide has shown weight loss approaching 24% or more in clinical trials, bringing outcomes closer to what was previously seen only with bariatric surgery

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The medication can activate GLP-1 and GIP receptors in circumventricular organsspecialized brain regions including the area postrema and median eminence that lack a complete blood-brain barrier