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Although DSM-5 diagnosis is defined through multiple behavioral criteria encompassing impaired control, social dysfunction, continued use despite harm, and tolerance or withdrawal, converging clinical and preclinical evidence indicates that the core pathological feature of SUDs is the progressive loss of control over intake (O'Brien, 2005)

doi: 10.1073/pnas.051599198 71 van WilligenGNieuwlandRNurnbergBGorterGAkkermanJW

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