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The authors discuss the preclinical literature and emerging clinical evidence that support the rationale for investigating the use of glucagon-like peptide-1 receptor agonists to prevent and treat several neurodegenerative diseases of aging, with a focus on Alzheimers disease.

Glucagon-like peptide-1 receptor agonists also lead to satiety and appetite reduction through action on the brains appetite regulation centers, leading to weight loss in obese patients

Akkermansia muciniphila produces P9, a small protein that interacts with ICAM-2 to increase thermogenesis and glucagon-like peptide-1 (GLP-1) secretion in mice

Research suggests that GLP-1 users prefer sugar to artificial sweeteners, as they are increasingly attracted to more 'natural' food that feels 'worthwhile' with their smaller appetites

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