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Because Pendulum can increase GLP-1 production, and GLP-1 affects insulin secretion, combining the supplement with insulin or sulfonylureas could theoretically increase hypoglycemia risk

Peak plasma concentration is achieved about 2 hours post administration

Meier JJ, Gethmann A, Nauck MA et al (2006) The glucagon-like peptide-1 metabolite GLP-1-(936) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans

These are rare with GLP-1 medications but require emergency response if they occur

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Eligibility is also determined based on an individuals overall health and medical history