glp-1 and dual glp-1/gip receptor agonists Tirzepatide's Unique Mechanism of Action The Emerging Role of Dual
Description
The discovery of the second incretin, GLP-1, originated from observations in 1982 that anglerfish proglucagon mRNA contained coding sequences of glucagon-related peptide, flanked by pairs of basic amino acids characteristic of the sites cleaved during post-translational processing of prohormones (19)
In clinical trials, once-weekly semaglutide at diabetes doses (0.51 mg) produces mean weight loss of 46 kg (913 lbs), while the 2.4 mg dose (Wegovy) achieves average weight reductions of 1215% of body weight
doi: 10.1056/NEJMp1314078
Lietzau et al., 2020)
Meyerholz DK, Lambertz AM, McCray PB
Cardiovasc Contin
