glp-1 addiction treatment receptor agonists show promise in treating substance use disorders GLP-1 Alcohol Cravings: How Ozempic
Description
They're found in places like the pancreas, gut, and brain
doi: 10.1111/andr.13296
These agents mimic the biological action of the native incretin hormone GLP-1 but are structurally modified to resist degradation by the enzyme dipeptidyl peptidase 4 (DPP-4), thereby extending their half-life and duration of action (Zheng et al., 2024
& Alberti, K
Larger Phase 3 trials (see Whats coming down the pike) will decide whether semaglutide graduates from off-label experiment to on-label therapy
In a 2024 joint court filing, the two companies said that the safety profile of GLP-1 RAs has been well-established in hundreds of clinical trials, large-scale observational studies, and nearly two decades of real-world use
