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Urine oxalate excretion is positively correlated with weight and BMI, and urinary oxalate is significantly higher in obese compared with lean adult calcium oxalate stone formers

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Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC heart failure long-term registry

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Additional insights come from the phase 3 STEP trial (STEP 3), which combined 2.4 mg semaglutide with an intensive low-calorie diet (10001200 kcal/day meal replacements for the first 8 weeks, followed by a hypocaloric diet of 12001800 kcal/day) and progressive increases in physical activity to 200 minutes per week [13]