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At 4 to 6 mg daily Nausea becomes more common, affecting roughly 20 to 30% of users at these levels

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Future NDD trials will likely need biological enrichment strategies (e.g., selecting BIR-positive or metabolically dysregulated individuals), combined with biomarker endpoints of central insulin signaling and stringent adherence frameworks, to reliably identify responders

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Non-Pharmacological Interventions and Technology Integration: Alongside medication, non-pharmacological interventions like diet, exercise, and behavioral therapy play a critical role in managing diabetes and obesity