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In addition, a membrane-bound zinc metallopeptidase, neutral endopeptidase 24.11 (NEP 24.11), has also been shown to cleave GLP-1 at its C terminus both in vitro and in vivo (Plamboeck et al., 2005)

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This pricing dynamic constrains overall market penetration and slows adoption despite the strong clinical benefits of GLP-1 therapies in weight management and glycemic control, making cost a key obstacle to broader global uptake

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