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While GLP-1 receptor agonists (such as semaglutide and liraglutide) have demonstrated significant benefits in diabetes management, weight reduction, and cardiovascular outcomes in clinical trials, enhancing physiological GLP-1 through dietary and lifestyle modifications represents a foundational approach

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Following this, the SURPASS-3 trial evaluated tirzepatide in patients with T2DM inadequately controlled by metformin, with or without SGLT2 inhibitors

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Tirzepatide is the symbol of the status quo, while retatrutide is the symbol of the near future