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Heart rate elevation and autonomic effects One of the most consistent physiological effects observed with GLP-1 RAs is a modest, dose-dependent increase in heart rate, typically ranging from 2 to 5 beats per minute

Clinical Application Guidance: Therapeutic selection should be individualized based on patient-specific factors, such as cardiovascular status, renal function, administration route preferences, and tolerability, with ongoing attention to emerging evidence to refine treatment strategies
Eur J Pharmacol 2021, 911
Eur J Sport Sci

Zhu E, Yang Y, Zhang J, Li Y, Li C, Chen L, et al

The achievement rate of the target BP increased from 25.4% after treatment to 33.3% after combination therapy ( p = 0.003)
