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Nat Rev Neurol 13(4):217231

[1] Dose-dependent effects are evident, with higher doses of semaglutide (7mg and 14mg) associated with increased frequency and severity of gastrointestinal symptoms compared to the 3mg starting dose

Metabolism, stress, sleep, and activity all have a role

Lower concentrations including 1.0 mg weekly generated clinically meaningful results approaching 10-11% weight reduction in study populations

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FDA approves oral semaglutide for type 2 diabetes, obesity indication pending The FDA has expanded oral semaglutides reach: now approved for CV risk reduction in type 2 diabetes, with an obesity indication decision expected soon