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These associations have sparked growing interest in repurposing antidiabetic drugs, particularly those that target insulin signaling, as potential disease-modifying therapies for PD

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

When dosed at 10 g kg 1 , both P5 and Ex4 significantly lowered fasting blood glucose levels (25%

Liraglutide treatment had a better influence on BMI and waist circumference reduction than combined therapy, but the latter significantly decreased total testosterone and caused less nausea [94]
