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GLP 1 receptor agonists and dual incretin therapies are delivering measurable, outcome driven results: 12% to 27% relative risk reduction in major adverse cardiovascular events across CVOTs 13% to 14% reduction in cardiovascular death in meta analyses 11% to 14% reduction in hospitalization for heart failure 24% relative risk reduction in kidney outcomes in the dedicated FLOW trial with semaglutide Up to 15.8% weight loss with semaglutide 2.4 mg 20.2% weight loss with tirzepatide 15 mg in head to head obesity trials 66% to 93% reduction in progression from prediabetes to type 2 diabetes This is no longer about glucose (or weight loss) alone

doi: 10.1016/S0140-6736(08)61246-5

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doi: 10.1210/clinem/dgz140 174 Ten KulveJSVeltmanDJVan BloemendaalLGrootPFCRuhHGBarkhofFet al

AMPK = adenosine monophosphate-activated protein kinase

Key hormones released by EECs include GLP-1, GIP, cholecystokinin (CCK), ghrelin, and peptide YY (PYY)