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Adding to the concerns, there is a growing market for compounded versions of GLP-1 drugs and peptides sold online

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Figure 1(II) demonstrates rats with FM induced by Reserpine presented an exacerbation in the urged pain response, as noted by the aberrations in the nociceptive reflexes through the decremented threshold of (A) the von Frey test (VFT) and (B) CAPWL, reaching 71% [F (2,27) = 6.376, p = 0.0053, 2 = 0.321] and 40% [F (2,27) = 20.12, p = 0.0003, 2 = 0.770], respectively, compared to the normal rats

These could signal something beyond typical adjustment effects