glp 1 agonist mechanism of action of GLP-1 agonists – My Endo Consult Frontiers | GLP-1 receptor agonist

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Whether these effects arise directly from GLP-1 receptor activation in testicular tissue or indirectly through systemic metabolic improvement remains unresolved

doi:10.1152/ajpregu.00519.2009 280

The binding of prorenin to PRR triggers the phosphorylation of mitogen-activated protein kinases/extracellular regulated kinases 1/2 (MAPK/ERK1/2), which is demonstrated to be an ANG II-independent mechanism involved in the development of diabetic nephropathy (25) The ANGIV/AT4/IRAP cascade: ANG IV (derived from the metabolization of ANG II through aminopeptidases A and N) binds the AT4 receptor, which has been identified as the insulin-regulated aminopeptidase (IRAP), but the role of this pathway in the blood pressure and renal regulation is still uncertain (22)

Maybe GLP-1 drugs seem to do everything because obesity (and high blood sugar) are broadly bad for you, and anything that reduces obesity (or high blood sugar) is broadly good for you

The useful question is no longer only how many scripts were supplied? It is: Which patients can access treatment, through which pathway, for which indication, at what cost, with what persistence, and with what outcome